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AβPP intracellular C-terminal domain function is related to its degradation processes

Erica Buoso1, Fabrizio Biundo, Cristina Lanni

  • 1Department of Drug Sciences, Pharmacology Unit, Center of Excellence in Applied Biology, University of Pavia, Pavia, Italy.

Journal of Alzheimer'S Disease : JAD
|March 28, 2012
PubMed
Summary

Amyloid-β precursor protein (AβPP) intracellular domain (AICD) plays a role in gene regulation. Its removal involves proteasome activity and an alternative IDE-inhibitor-sensitive pathway, suggesting dual degradation mechanisms.

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