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Neuroplasticity-based computerized cognitive remediation for geriatric depression.

Sarah Shizuko Morimoto¹, Bruce E Wexler, George S Alexopoulos

¹Department of Psychiatry, Institute of Geriatric Psychiatry, Weill Cornell Medical College, White Plains, NY, USA. ssm9006@med.cornell.edu

International Journal of Geriatric Psychiatry

|March 28, 2012

Summary

This summary is machine-generated.

Neuroplasticity-based computerized cognitive remediation (NBCCR) offers a novel approach for geriatric depression by targeting executive dysfunction. This intervention shows potential for improving cognitive function and mood in older adults unresponsive to traditional treatments.

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Area of Science:

Geriatric Psychiatry
Neuroscience
Cognitive Rehabilitation

Background:

Conventional treatments for geriatric depression have limitations, leaving many older adults with persistent symptoms.
Existing psychotherapies lack stringent efficacy criteria for acute geriatric depression treatment.
There is a need for novel interventions targeting treatment-resistant geriatric depression.

Purpose of the Study:

To describe a novel treatment model for geriatric depression using neuroplasticity-based computerized cognitive remediation (NBCCR).
To identify specific neurocognitive deficits and their neurobiological underpinnings in geriatric depression.
To propose a strategy for research into NBCCR for geriatric depression.

Main Methods:

Identification of specific executive deficits and their neurobiological basis.
Development of a computerized cognitive remediation strategy targeting these deficits.
Proposal for future research examining behavioral and neurobiological outcomes.

Main Results:

Executive dysfunction is a key target for NBCCR in geriatric depression.
NBCCR has the potential to improve executive function and mood.
Further research is needed to validate NBCCR's efficacy and mechanisms.

Conclusions:

Targeted NBCCR presents a promising novel treatment for geriatric depression.
Addressing pathophysiological changes linked to executive dysfunction is a viable strategy.
Investigating behavioral and neuroimaging changes can elucidate NBCCR's role in geriatric depression treatment.