Related Experiment Video
Updated: May 23, 2026
Simultaneous Detection of Different Antibody Classes in a Multiplexed Serological Test
Published on: July 14, 2023
Comparative evaluation of seven commercial tests for detection of heterophile antibody in infectious mononucleosis
M Skulnick1, D E Low, A E Simor
1Department of Microbiology, Mount Sinai Hospital, University of Toronto; and Department of Virology, Ministry of Health Laboratory Services Branch, Toronto, Ontario.
Abstract:
Detection of heterophile antibodies in infectious mononucleosis is the most rapid and cost-effective method for confirming the clinical diagnosis of the disease. This study compared seven commercial test kits (the Oxoid Infectious Mononucleosis Kit [Oxoid Ltd], Immunoscan Im-Latex [Baxter Travenol], Mono-Latex [Wampole Laboratories], Monospot and Im Screen Test [Ortho Diagnostics], Immunoscan Im-RBC Test [Baxter Travenol], and Infectious Mononucleosis Test [NCS Diagnostics]) to the Davidsohn differential test. All of the kits were shown to be acceptable for use, with specificities and sensitivities greater than 96.5% and 95.5%, respectively.
