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Related Concept Videos

Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Renal Regulation of Acid-Base Balance01:29

Renal Regulation of Acid-Base Balance

Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...

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Updated: May 23, 2026

Using Herbal-Cake-Separated Moxibustion for the Treatment of Rats with Chronic Renal Failure
06:46

Using Herbal-Cake-Separated Moxibustion for the Treatment of Rats with Chronic Renal Failure

Published on: December 22, 2023

[Renal amyloidosis].

P Cuchard1, R Cuchard, S Rotman

  • 1Hôpital Riviera, Site de la Providence, Vevey. pamela.cuchard@hopital-riviera.ch

Revue Medicale Suisse
|March 29, 2012
PubMed
Summary
This summary is machine-generated.

Amyloidosis involves protein buildup in organs, primarily affecting kidneys and heart. Treatment targets the cause, but prognosis remains poor, especially for dialysis patients.

Related Experiment Videos

Last Updated: May 23, 2026

Using Herbal-Cake-Separated Moxibustion for the Treatment of Rats with Chronic Renal Failure
06:46

Using Herbal-Cake-Separated Moxibustion for the Treatment of Rats with Chronic Renal Failure

Published on: December 22, 2023

Area of Science:

  • Medicine
  • Pathology
  • Biochemistry

Background:

  • Amyloidosis is characterized by extracellular deposition of misfolded proteins forming beta-pleated sheets.
  • Over 17 distinct types of amyloidosis have been identified, with systemic light chain (AL) and AA amyloidosis being most prevalent.
  • AL amyloidosis commonly affects the kidneys, heart, and gastrointestinal tract.

Observation:

  • Diagnosis of amyloidosis is confirmed solely through tissue biopsy.
  • Systemic forms frequently involve vital organs such as the kidneys and heart.
  • Prognosis is generally poor, significantly influenced by the extent of organ involvement.

Findings:

  • Treatment for primary (AL) amyloidosis focuses on eradicating the causative plasma cell clone.
  • Secondary amyloidosis (AA) treatment involves managing the underlying chronic inflammatory condition.
  • Cardiac and renal involvement are critical prognostic indicators, with dialysis patients facing a worse outlook.

Implications:

  • Effective amyloidosis management requires early diagnosis and targeted therapy based on amyloid type.
  • Understanding organ-specific involvement is crucial for predicting patient outcomes.
  • Further research into novel therapeutic strategies is needed to improve survival rates in advanced amyloidosis.