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Updated: May 23, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
A novel pathway of photoinduced decomposition of sphingolipids
Alexandra G Lisovskaya1, Irina P Edimecheva, Oleg I Shadyro
1Department of Chemistry, Belarusian State University, Minsk, Belarus.
Abstract:
A possibility of a novel photodestruction process has been shown for sphingolipids and their low-molecular analogues, including the stage of Norrish Type-I decomposition of excited molecules of the starting compounds followed by fragmentation of nitrogen-centered radicals via rupture of the C-C and O-H bonds. Realization of such transformation during photolysis of ceramide, sphingomyelin and galactocerebroside results in formation of 2-hexadecenal, which possess a wide spectrum of biological activity.
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