Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoregulatory cell dysfunction in chronic B-cell leukemias.

S L Zaknoen1, N E Kay

  • 1Department of Medicine, University of Minnesota.

Blood Reviews
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamics of microvesicle generation in B-cell chronic lymphocytic leukemia: implication in disease progression.

Leukemia·2016
Same author

Genomic characterization of high-count MBL cases indicates that early detection of driver mutations and subclonal expansion are predictors of adverse clinical outcome.

Leukemia·2016
Same author

Heterogeneity of CD5 Membrane Expression on B-Chronic Lymphocytic Leukemia Cells.

Leukemia & lymphoma·2016
Same author

Interferon in the Treatment of Refractory Multiple Myeloma: An Eastern Cooperative Oncology Group Study.

Leukemia & lymphoma·2016
Same author

A progression-risk score to predict treatment-free survival for early stage chronic lymphocytic leukemia patients.

Leukemia·2015
Same author

Axl activates fibroblast growth factor receptor pathway to potentiate survival signals in B-cell chronic lymphocytic leukemia cells.

Leukemia·2015
Same journal

Treating large B-cell lymphoma: Current strategies and unmet needs across community and academic settings.

Blood reviews·2026
Same journal

MRD in multiple myeloma: Moving from "minimal" to "measurable".

Blood reviews·2026
Same journal

PRISMA-based systematic review on iron stores in repeat blood donors.

Blood reviews·2026
Same journal

Artificial intelligence applications in thrombotic thrombocytopenic Purpura: A systematic review of diagnostic, risk stratification, and prognostic models.

Blood reviews·2026
Same journal

Antibacterial, antifungal and antiviral prophylaxis and vaccination strategies in adult patients with acute myeloid and promyelocytic leukemia: An expert panel consensus from the GIMEMA group.

Blood reviews·2026
Same journal

The Lebanese national patient blood management guidelines: A new page in the medical practice.

Blood reviews·2026
See all related articles

This review examines immune cell abnormalities in chronic B-cell malignancies like leukemia and myeloma. It highlights changes in T-cells, NK cells, and monocytes, and their impact on disease progression and complications.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Chronic B-cell malignancies, including chronic lymphocytic leukemia, multiple myeloma, and hairy cell leukemia, are clonal B-cell disorders.
  • These diseases are characterized by the uncontrolled proliferation of malignant B-cells.
  • Secondary abnormalities in non-malignant cells contribute to the disease process and its complications.

Purpose of the Study:

  • To review the alterations in immunoregulatory (IR) cells within the context of chronic B-cell malignancies.
  • To focus on the qualitative and quantitative changes in T-cells, natural killer (NK) cells, and monocytes.
  • To emphasize the relevance of these IR cell changes to the pathogenesis and complications of these hematologic cancers.

Main Methods:

  • Literature review focusing on secondary abnormalities in non-malignant cells in chronic B-cell malignancies.

Related Experiment Videos

  • Analysis of qualitative and quantitative aspects of T-cells, NK cells, and monocytes.
  • Synthesis of information regarding the impact of IR cell dysfunction on disease progression.

    • Main Results:

    • Significant qualitative and quantitative abnormalities are observed in T-cells, NK cells, and monocytes in patients with chronic B-cell malignancies.
    • These immune dysregulations are not merely epiphenomena but play a role in the disease process.
    • IR cell alterations are linked to increased susceptibility to infections and other disease complications.

    Conclusions:

    • Immunoregulatory cell abnormalities are a critical feature of chronic B-cell malignancies.
    • Understanding these changes is crucial for managing disease progression and patient outcomes.
    • Targeting IR cell dysfunction may offer novel therapeutic strategies for these hematologic neoplasms.