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Related Concept Videos

Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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Next-generation Sequencing

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Sanger Sequencing01:57

Sanger Sequencing

DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
RNA-seq03:21

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
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Gene Evolution - Fast or Slow?02:05

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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Multi-species Conserved Sequences

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Christopher E Mason1, Olivier Elemento

  • 1Weill Cornell Medical College, Institute for Computational Biomedicine, Department of Physiology and Biophysics, New York, NY 10021, USA. chm2042@med.cornell.edu

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|March 29, 2012
PubMed
Summary
This summary is machine-generated.

This report summarizes key advances in genome biology and technology presented at the 2012 AGBT meeting. Discover the latest innovations in genomic research and applications.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Biotechnology

Background:

  • The Advances in Genome Biology and Technology (AGBT) meeting is a premier event for researchers in the field.
  • The 2012 meeting focused on cutting-edge developments and future directions in genomic technologies.

Purpose of the Study:

  • To provide a comprehensive overview of the scientific content presented at AGBT 2012.
  • To highlight significant findings and emerging trends in genome biology and technology.

Main Methods:

  • The report is based on presentations, discussions, and keynotes from the AGBT 2012 conference.
  • Information was gathered from various sessions covering sequencing, data analysis, and applications.

Main Results:

  • Significant progress was reported in next-generation sequencing (NGS) platforms and their applications.
  • New tools and methodologies for large-scale genomic data analysis were showcased.
  • Advances in fields such as epigenomics, transcriptomics, and synthetic biology were discussed.

Conclusions:

  • The AGBT 2012 meeting underscored the rapid pace of innovation in genome biology and technology.
  • Continued advancements promise to accelerate biological discovery and drive technological development.