Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Modern Molecular Taxonomy

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multi-ancestry transcriptome-wide association studies uncover insights into breast cancer genetics and biology.

Nature communications·2026

Same author

Long-Term Outcomes of Patients With BRCA+ or PALB2+ Pancreatic Cancer Treated With Maintenance Rucaparib: A Secondary Analysis of a Nonrandomized Clinical Trial.

JAMA oncology·2026

Same author

Comparative analysis of distinct genomic landscapes in young-onset gBRCA1/2 breast cancer.

JCI insight·2026

Same author

A randomized study of digital versus genetic counselor return of actionable genetic research results to biobank participants (RESPECT3 study).

BMC medical ethics·2026

Same author

Homologous recombination deficiency and hemizygosity drive resistance in breast cancer.

Nature·2026

Same author

Association of Y-chromosomal gr/gr deletions with testicular germ cell tumor: whole-genome analysis of 198,306 individuals.

medRxiv : the preprint server for health sciences·2026

Same journal

Present and Emerging Strategies for Disease Assessment in Hodgkin Lymphoma.

Cancer journal (Sudbury, Mass.)·2026

Same journal

Nodular Lymphocyte-predominant Hodgkin Lymphoma: Incidence, Pathogenesis, Management.

Cancer journal (Sudbury, Mass.)·2026

Same journal

Management of Classic Hodgkin Lymphoma in Special Clinical Situations.

Cancer journal (Sudbury, Mass.)·2026

Same journal

Older Patients With Hodgkin Lymphoma: A Contemporary Review.

Cancer journal (Sudbury, Mass.)·2026

Same journal

Adolescent and Young Adult Patients With Classical Hodgkin Lymphoma: A Review as a Case Study in AYA Cancer Care.

Cancer journal (Sudbury, Mass.)·2026

Same journal

Hodgkin Lymphoma: Management of Patients Who Fail Primary Therapy.

Cancer journal (Sudbury, Mass.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 23, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Molecular testing in melanoma.

Melissa Ann Wilson¹, Katherine L Nathanson

¹Division of Hematology and Oncology, Department of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.

Cancer Journal (Sudbury, Mass.)

|March 29, 2012

Summary

This summary is machine-generated.

Identifying melanoma mutations is key for effective cancer treatment. This review discusses methods to detect genetic changes, aiding personalized medicine and clinical trial selection for better patient outcomes.

More Related Videos

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model

Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model

Published on: November 13, 2012

Related Experiment Videos

Last Updated: May 23, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model

Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model

Published on: November 13, 2012

Area of Science:

Oncology
Genetics
Dermatology

Background:

Melanoma incidence is rising, and current treatments rarely achieve a cure.
Somatic mutations are crucial in melanoma development, necessitating accurate identification.
Personalized medicine approaches require precise understanding of tumor genetic profiles.

Purpose of the Study:

To review techniques for identifying genetic mutations and genomic aberrations in melanoma.
To discuss the strengths, weaknesses, and limitations of various mutation detection strategies.
To highlight the importance of mutation identification for patient stratification and clinical trial eligibility.

Main Methods:

Review of existing techniques for genetic mutation detection in melanoma samples.
Analysis of factors influencing the choice of mutation detection strategy (mutation type, sample number).
Discussion of the comparative performance of different diagnostic methods.

Main Results:

Various methods exist for detecting genetic mutations and genomic aberrations in melanoma.
The selection of a detection strategy depends on mutation type and sample characteristics.
Understanding mutation profiles is essential for advancing melanoma treatment.

Conclusions:

Accurate identification of melanoma somatic mutations is vital for patient stratification and treatment.
Continued development of mutation detection techniques will advance personalized medicine in melanoma care.
Understanding tumor pathogenesis through mutation discovery aids clinical decision-making.