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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: May 23, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Surgery for distant melanoma metastasis.

Anna M Leung1, Danielle M Hari, Donald L Morton

  • 1Department of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA.

Cancer Journal (Sudbury, Mass.)
|March 29, 2012
PubMed
Summary
This summary is machine-generated.

Distant metastatic melanoma treatment is improving with new therapies like vemurafenib and ipilimumab. Surgical resection, when complete (R0), is effective for advanced melanoma, especially when combined with systemic treatments.

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Last Updated: May 23, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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Published on: January 25, 2015

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08:49

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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Area of Science:

  • Oncology
  • Surgical Oncology
  • Dermatology

Background:

  • Metastatic melanoma historically had a poor prognosis due to limited effective treatments.
  • Recent advancements include U.S. Food and Drug Administration-approved biological therapies like vemurafenib and ipilimumab, significantly improving stage IV melanoma outcomes.

Purpose of the Study:

  • To evaluate the role of surgical resection in managing advanced metastatic melanoma.
  • To explore the combination of systemic therapies and surgical intervention for stage IV melanoma.

Main Methods:

  • Review of single-institution studies advocating for therapeutic surgical intervention in metastatic melanoma.
  • Analysis of factors influencing the efficacy of surgical resection, emphasizing complete disease removal (R0).

Main Results:

  • Surgical resection can be effective in advanced melanoma if all disease is removed (R0).
  • Patient selection is critical for successful surgical outcomes in metastatic melanoma.
  • The combination of novel systemic therapies and surgical resection is an area of ongoing investigation.

Conclusions:

  • New biological therapies have transformed stage IV melanoma treatment.
  • Surgical resection, when R0, remains a viable option for advanced melanoma, particularly when combined with systemic treatments.
  • Further understanding of melanoma tumor biology and metastasis is essential for optimizing treatment strategies.