Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The synergic effect of Multiparametric MRI and [<sup>18</sup>F]PSMA-1007 PET/CT imaging in recurrence work-up of locally advanced prostate adenocarcinoma.

Revista espanola de medicina nuclear e imagen molecular..·2025

Same author

Unique [<sup>18</sup>F]FDG PET imaging pattern of drug-induced acute generalized exanthematous pustulosis within the SCAR-spectrum.

European journal of nuclear medicine and molecular imaging·2022

Same author

PSMA-1007 Uptake in Ganglia of the Sympathetic Trunk and Its Intra-individual Reproducibility.

Molecular imaging and biology·2022

Same author

Distinguishing Benign and Malignant Findings on [<sup>68</sup> Ga]-FAPI PET/CT Based on Quantitative SUV Measurements.

Molecular imaging and biology·2022

Same author

Detecting and Locating the Site of Local Relapse Using <sup>18</sup>F-PSMA-1007 Imaging After Primary Treatment of 135 Prostate Cancer Patients-Potential Impact on PSMA-Guided Radiation Therapy.

Molecular imaging and biology·2022

Same author

Head-to-head Intra-individual Comparison of [<sup>68</sup>Ga]-FAPI and [<sup>18</sup>F]-FDG PET/CT in Patients with Bladder Cancer.

Molecular imaging and biology·2022

Search research articles

Related Experiment Video

Updated: May 23, 2026

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Published on: July 7, 2023

Cancer with unknown primary: finding a needle in a hay stack.

F L Giesel¹, A Mehndiratta, M P Mafomane

¹Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany. f.giesel@dkfz.de

Experimental Oncology

|March 29, 2012

Summary

Detecting small neuroendocrine tumors (NET) is challenging. Advanced imaging like Gallium-68 DOTATOC PET/CT and Technetium-99m Octreotide SPECT/CT aid in diagnosing and surgically removing these NETs.

More Related Videos

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Related Experiment Videos

Last Updated: May 23, 2026

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Published on: July 7, 2023

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Area of Science:

Nuclear Medicine
Oncology
Surgical Oncology

Background:

Neuroendocrine tumors (NETs) are often diagnosed late due to their small size, complicating detection and resection.
Somatostatin receptor (SSR) expression is a key characteristic of many NETs, making them targets for specific imaging agents.

Observation:

Positron Emission Tomography/Computed Tomography (PET/CT) using Gallium-68 DOTATOC ((68)Ga-DOTATOC) demonstrates high sensitivity and specificity for NET cells expressing SSRs.
Intraoperative detection of NETs can be enhanced using Technetium-99m Octreotide ((99m)Tc-Octreotide) SPECT/CT, assisting surgeons during resection.

Findings:

This clinical case highlights the successful application of both (68)Ga-DOTATOC PET/CT and (99m)Tc-Octreotide SPECT/CT in the diagnostic and therapeutic management of a patient with NET.
The combined use of these nuclear imaging modalities facilitated precise localization and complete surgical removal of a small NET.

Implications:

These findings underscore the value of advanced nuclear imaging techniques in improving the diagnostic accuracy and surgical outcomes for patients with neuroendocrine tumors.
Integrating (68)Ga-DOTATOC PET/CT and (99m)Tc-Octreotide SPECT/CT offers a powerful strategy for the comprehensive management of NETs, from initial diagnosis to surgical intervention.