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Related Experiment Video

Updated: May 23, 2026

Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents
07:42

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Published on: April 25, 2017

Sacral neuromodulation for nonobstructive urinary retention: a meta-analysis.

Carey Gross1, Mounira Habli, Christopher Lindsell

  • 1From the Departments of *Obstetrics and Gynecology, and †Emergency Medicine, University of Cincinnati, Cincinnati, OH.

Female Pelvic Medicine & Reconstructive Surgery
|March 29, 2012
PubMed
Summary
This summary is machine-generated.

Sacral neuromodulation (InterStim) effectively treats nonobstructive urinary retention by significantly reducing post-void residual volume and increasing voided volume. This therapy offers a promising solution for patients experiencing urinary retention.

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Last Updated: May 23, 2026

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Published on: August 28, 2020

Area of Science:

  • Urology
  • Neurology
  • Medical Devices

Background:

  • Nonobstructive urinary retention (NUR) presents a significant clinical challenge.
  • Current treatment options for NUR may have limited efficacy or side effects.
  • Sacral neuromodulation offers a potential therapeutic avenue for NUR.

Purpose of the Study:

  • To systematically review the existing literature on the efficacy of sacral neuromodulation (InterStim) for treating nonobstructive urinary retention.
  • To evaluate the impact of sacral neuromodulation on key urinary function parameters in patients with NUR.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (PubMed, Cochrane, EMBASE, Web of Science, Scopus) from 1980 to 2008.
  • Studies involving sacral neuromodulation for NUR with implanted generators were included.
  • Primary outcomes included changes in pre- and postoperative postvoid residual and voided volume.

Main Results:

  • Fourteen articles met inclusion criteria, including one RCT and 13 observational studies.
  • Sacral neuromodulation led to a significant mean decrease in postvoid residual of 236 mL (P < 0.00001).
  • Voided volume significantly increased by a mean of 299 mL (P < 0.00001).

Conclusions:

  • Sacral neuromodulation (InterStim) is an effective treatment for nonobstructive urinary retention.
  • The therapy demonstrates significant improvements in both urine retention and voiding efficiency.
  • Further research may explore long-term outcomes and patient selection criteria.