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Updated: May 23, 2026
Placement of Extracranial Stimulating Electrodes and Measurement of Cerebral Blood Flow and Intracranial Electrical Fields in Anesthetized Mice
Published on: June 2, 2023
Depth-dependent cerebral hemodynamic responses following direct cortical electrical stimulation (DCES) revealed by in
Seungduk Lee1, Dalkwon Koh, Areum Jo
1Department of Biomicrosystem Engineering, Korea University, Jeongneung 3-dong, Seongbuk-ku, Seoul 136-703, South Korea.
Abstract:
We studied depth-dependent cerebral hemodynamic responses of rat brain following direct cortical electrical stimulation (DCES) in vivo with optical recording of intrinsic signal (ORIS) and near-infrared spectroscopy (NIRS). ORIS is used to visualize the immediate hemodynamic changes in cortical areas following the stimulation, whereas NIRS measures the hemodynamic changes originating from subcortical areas. We found strong hemodynamic changes in relation to DCES both in ORIS and NIRS data. In particular, the signals originating from cortical areas exhibited a tri-phasic response, whereas those originating from subcortical regions exhibited multi-phasic responses. In addition, NIRS signals from two different sets of source-detector separation were compared and analyzed to investigate the causality of perfusion, which demonstrated downstream propagation, indicating that the upper brain region reacted faster than the deep region.
