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Updated: May 23, 2026
Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging
Published on: June 26, 2017
Adaptive synthetic-aperture focusing technique for microvasculature imaging using photoacoustic microscopy
Zilin Deng1, Xiaoquan Yang, Hui Gong
1Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong, University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China.
Abstract:
To improve the lateral resolution of the blood vessels along arbitrary direction out of focus in photoacoustic microscopy (PAM), we propose an adaptive synthetic-aperture focusing technique (ASAFT) for microvasculature imaging which can be automatically applied to each branch of blood vessels, based on our previous two-dimensional (2D) SAFT. The ASAFT is validated both in the phantom study and in vivo imaging. The results demonstrate that ASAFT can provide images of blood vessels with better lateral resolution both at different depths and along various directions compared with one-dimensional and 2D SAFT.
