Related Experiment Video

Updated: May 23, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Vitamin D status in children with chronic kidney disease

Deborah R Stein1, Henry A Feldman, Catherine M Gordon

  • 1Department of Pediatrics, Children's Hospital Boston, Boston, MA, USA. deborah.stein@childrens.harvard.edu

Pediatric Nephrology (Berlin, Germany)
|March 29, 2012
PubMed

Insights

Vitamin D deficiency is common in children with chronic kidney disease (CKD). Optimizing vitamin D levels may help manage hyperparathyroidism in pediatric CKD patients.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Nutritional Science

Background:

  • Disordered mineral metabolism in chronic kidney disease (CKD) is linked to significant morbidity and mortality.
  • Vitamin D status, dietary intake, and parathyroid hormone (PTH) secretion are critical in CKD patients.

Purpose of the Study:

  • To investigate vitamin D status and its relationship with PTH in pediatric CKD patients.
  • To assess the prevalence of vitamin D deficiency and insufficiency in this population.

Main Methods:

  • Cross-sectional study of 100 pediatric CKD patients (stages 1-5).
  • Measured serum levels of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)(2)D].
  • Collected data on parathyroid hormone (PTH) levels and nutrient intake.

Main Results:

  • 40% of patients had suboptimal serum 25(OH)D levels (deficient or insufficient).
  • No correlation was found between serum 25(OH)D and dietary vitamin D intake.
  • A significant relationship was observed between 25(OH)D and PTH levels.

Conclusions:

  • High prevalence of hyperparathyroidism in early-stage pediatric CKD.
  • Optimizing vitamin D levels may help prevent or improve hyperparathyroidism in early CKD.
  • Vitamin D optimization is likely important as adjunctive therapy in advanced pediatric CKD.
Abstract

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...