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Updated: May 23, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
Metal-free TEMPO-catalyzed oxidative C-C bond formation from Csp3-H bonds using molecular oxygen as the oxidant
Abstract:
An efficient TEMPO-catalyzed oxidative C-C bond formation with two Csp(3)-H bonds using molecular oxygen as the oxidant has been developed. The novel transformation provides a new strategy for the TEMPO-O(2) catalysis to construct C-C bonds. The advantages of this method include: (1) relatively mild and neutral conditions; (2) simplicity and safety of operation; (3) a stoichiometric amount of dangerous oxidants, any transition metals, additives, even solvent, is not required.
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