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Related Experiment Video

Updated: May 23, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

Closure of interatrial defects by immediate-release patch.

Aliakbar Zeinaloo¹, Keyhan Sayadpour Zanjani, Bahman Rastkar

¹Children's Medical Center, Tehran University of Medical Sciences, 62 Dr Gharib Street, 14194, Tehran, Iran.

Pediatric Cardiology

|March 29, 2012

Summary

The novel Immediate-Release Patch offers a wireless, bioabsorbable solution for closing cardiac defects. While generally successful, some residual shunts may occur, requiring further evaluation.

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Area of Science:

Cardiovascular Medicine
Biomaterials Science
Medical Devices

Background:

Cardiac defects necessitate effective closure methods.
Transcatheter devices offer less invasive treatment options.
Bioabsorbable materials present advantages in medical implants.

Purpose of the Study:

To evaluate the safety and efficacy of the Immediate-Release Patch for cardiac defect closure.
To assess the performance of this novel bioabsorbable device in clinical practice.

Main Methods:

The Immediate-Release Patch was used to attempt closure of 12 atrial septal defects and 1 fenestration.
Device implantation success, retrieval, and adverse events were recorded.
Follow-up assessments evaluated residual shunts and defect closure status.

Main Results:

Successful implantation was achieved in 12 out of 13 attempted procedures.
One device dislodged and was percutaneously retrieved; no other major adverse events were reported.
At a median 11-month follow-up, two patients had trivial residual shunts, and one had a significant residual defect.

Conclusions:

The Immediate-Release Patch demonstrates potential as a wireless, bioabsorbable device for cardiac defect closure, with advantages in specific defect types and sizes.
The device's bulkiness and application method require operator adaptation.
Further studies are needed to optimize outcomes and minimize residual shunts.