Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Oscillations In An LC Circuit01:30

Oscillations In An LC Circuit

An idealized LC circuit of zero resistance can oscillate without any source of emf by shifting the energy stored in the circuit between the electric and magnetic fields. In such an LC circuit, if the capacitor contains a charge q before the switch is closed, then all the energy of the circuit is initially stored in the electric field of the capacitor. This energy is given by
Brain Waves01:23

Brain Waves

Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanistic insights into hydroxy(tosyloxy)iodobenzene-mediated ditosyloxylation of chalcones: a DFT study.

Beilstein journal of organic chemistry·2025
Same author

Robotic patch repair of a ventricular septal aneurysm during an aortic valve replacement surgery.

Multimedia manual of cardiothoracic surgery : MMCTS·2025
Same author

Robotic Aortic Annular Enlargement With Y-Incision and Rectangular Patch.

Innovations (Philadelphia, Pa.)·2025
Same author

Computation of the Face Index of Certain Polycyclic Aromatic Hydrocarbons.

ACS omega·2025
Same author

Unveiling the Marvels of 3D Echo: <i>Illuminating prosthetic mitral valve dehiscence through 3D transillumination</i>.

Sultan Qaboos University medical journal·2025
Same author

Significance of ca15-3 in carcinoma of the breast with Visceral metastases.

Journal of Ayub Medical College, Abbottabad :, JAMC..·2024
Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026
Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026
Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026
Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: May 23, 2026

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
09:07

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

Published on: February 18, 2020

Calcium oscillations and waves in cells.

Jai Parkash1, Kamlesh Asotra

  • 1Department of Environmental and Occupational Health, Robert Stempel College of Public Health and Social Work, Florida International University, 11200 SW 8th Street, HLS-594, Miami, FL 33199, USA. parkashj@fiu.edu

Advances in Experimental Medicine and Biology
|March 29, 2012
PubMed
Summary
This summary is machine-generated.

Calcium (Ca2+) acts as a vital cell messenger throughout life. Recent findings suggest Ca2+ signals are driven by fluctuations, challenging traditional models and offering new insights into cell physiology.

More Related Videos

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
10:46

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ
09:34

Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ

Published on: January 7, 2019

Related Experiment Videos

Last Updated: May 23, 2026

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
09:07

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis

Published on: February 18, 2020

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
10:46

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ
09:34

Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ

Published on: January 7, 2019

Area of Science:

  • Cellular Biology
  • Biophysics
  • Signaling Pathways

Background:

  • Intracellular calcium concentration ([Ca2+]i) is tightly regulated, with resting levels around 100 nM maintained by a steep gradient.
  • Calcium signals manifest as transient spikes and regenerative waves, crucial for cellular communication.
  • Internal calcium stores significantly influence the dynamics of these signals.

Purpose of the Study:

  • To investigate the stochastic nature of intracellular calcium ([Ca2+]i) signaling.
  • To explore the role of fluctuation-driven mechanisms in calcium dynamics.
  • To understand the link between molecular fluctuations and whole-cell signaling.

Main Methods:

  • Analysis of regenerative calcium waves and their local initiation.
  • Investigation of hierarchical signaling structures and their impact on cellular responses.
  • Comparison of fluctuation-driven models with deterministic reaction-diffusion systems.

Main Results:

  • Global calcium oscillations emerge from locally initiated calcium waves, leading to stochastic patterns.
  • Hierarchical signaling structures amplify single-channel fluctuations, creating stochastic cellular media.
  • Evidence suggests intracellular calcium ([Ca2+]i) changes are primarily fluctuation-driven, not deterministic.

Conclusions:

  • Calcium signaling exhibits inherent stochasticity, originating from local wave dynamics.
  • Fluctuation-driven mechanisms are critical for understanding calcium signal generation.
  • Elucidating these stochastic processes enhances knowledge of cell signaling and physiology.