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Platelet aggregation of migraineurs during and between attacks
1Institute of Neurology, Semmelweis Medical University, Budapest, Hungary.
Abstract:
Platelet aggregation induced by ADP, collagen and platelet-activating factor was studied in common (migraine without aura) and classical migraine (migraine with aura) patients during and between attacks. The EC50* values for ADP and platelet-activating factor were significantly higher, whilst that for collagen was significantly lower in classical migraine patients during headache-free intervals compared to healthy volunteers. The EC50 values obtained for common migraine sufferers during symptom-free periods were similar to those of controls. During attacks, the EC50 value for ADP, but not for collagen and platelet-activating factor, was significantly higher than that of the controls. In healthy subjects a positive correlation was found between ADP and collagen-induced aggregation. In contrast, there was a U-shaped correlation matrix in classical migraine patients. The present observations show that platelet aggregation is altered in migraine patients and this raises the possibility that platelet-activating factor may be involved in the pathogenesis of migraine.
Insights
Platelet aggregation differs in migraine patients, particularly those with classical migraine, suggesting platelet-activating factor may play a role in migraine pathogenesis.
Area of Science:
- Neurology
- Hematology
- Biochemistry
Background:
- Platelet aggregation plays a crucial role in hemostasis and thrombosis.
- Migraine, a complex neurological disorder, may involve vascular and platelet abnormalities.
Purpose of the Study:
- To investigate alterations in platelet aggregation in patients with common and classical migraine.
- To compare platelet aggregation responses to adenosine diphosphate (ADP), collagen, and platelet-activating factor (PAF) between migraineurs and healthy controls.
Main Methods:
- Platelet aggregation was measured in common migraine (migraine without aura) and classical migraine (migraine with aura) patients during and between attacks.
- Adenosine diphosphate (ADP), collagen, and platelet-activating factor (PAF) were used as agonists.
- EC50 values and correlation matrices were analyzed.
Main Results:
- Classical migraine patients showed higher EC50 for ADP and PAF, and lower EC50 for collagen during headache-free intervals compared to controls.
- Common migraine patients exhibited EC50 values similar to controls during symptom-free periods.
- During attacks, only the EC50 for ADP was significantly higher in migraine patients compared to controls.
- A U-shaped correlation was observed between ADP and collagen-induced aggregation in classical migraine patients, unlike the positive correlation in healthy subjects.
Conclusions:
- Platelet aggregation is altered in migraine patients, with distinct patterns observed in classical migraine.
- These findings suggest a potential role for platelet dysfunction and platelet-activating factor (PAF) in the pathogenesis of migraine.