Association between a Primitive Brain Tumor and Cerebral Aspergillosis

Related Experiment Video

Updated: May 23, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Siegfried Hélage1, Charles Duyckaerts, Danielle Seilhean

  • 1Laboratoire de Neuropathologie Escourolle, Institut du Cerveau et de la Moelle épinière, Université Pierre et Marie Curie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 47-83 boulevard de l'Hôpital, 75651 Paris cedex 13, France.

Case Reports in Medicine
|March 29, 2012
PubMed

Insights

Cerebral aspergillosis, a rare central nervous system infection, has a poor prognosis even with antifungal treatment. This case highlights its lethal outcome in an infiltrative glioma patient undergoing corticotherapy and radiotherapy.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Oncology

Background:

  • Cerebral aspergillosis is a rare and severe central nervous system infection.
  • It often arises from invasive pulmonary aspergillosis with hematogenous spread.
  • Risk factors include immunocompromise, prolonged corticotherapy, or chemoradiotherapy for cancer.

Observation:

  • A case of a patient with an infiltrative glioma is presented.
  • The patient received corticotherapy and radiotherapy for their cancer.
  • This led to the development of cerebral aspergillosis.

Findings:

  • The cerebral aspergillosis in this patient was lethal.
  • Clinicopathological aspects of this rare fungal infection were described.
  • The therapeutic approach for this specific case was detailed.

Implications:

  • This case underscores the poor prognosis of cerebral aspergillosis.
  • It highlights the potential risk in cancer patients undergoing specific treatments.
  • Further research into effective therapeutic strategies for CNS aspergillosis is warranted.

More Related Videos

Concomitant Isolation of Primary Astrocytes and Microglia for Protozoa Parasite Infection09:34

Concomitant Isolation of Primary Astrocytes and Microglia for Protozoa Parasite Infection

Published on: March 18, 2020

Related Concept Videos

Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...