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Related Experiment Video

Updated: May 23, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

CNS diseases and uveitis.

Pia Allegri¹, Roberto Rissotto, Carl P Herbort

¹Uveitis Center, Ophthalmology Department, Rapallo Hospital, Genova, Italy.

Journal of Ophthalmic & Vision Research

|March 29, 2012

Summary

Ocular and central nervous system (CNS) disorders present diagnostic challenges due to overlapping symptoms. This review guides diagnosis and treatment of inflammatory, infectious, and autoimmune conditions affecting both the eye and CNS.

Keywords:

CNS Inflammatory and Infectious Diseases Eye Inflammatory and Infectious Diseases Uveitis

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Last Updated: May 23, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

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Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

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Area of Science:

Neuro-ophthalmology
Neurology
Immunology

Background:

Concurrent or sequential disorders of the eye and central nervous system (CNS) are common.
Inflammatory, infectious, neoplastic, and idiopathic conditions can affect both systems.
Similar ocular and neurological manifestations pose diagnostic challenges.

Purpose of the Study:

To review major neurological syndromes affecting the eye.
To provide a guide for diagnosing and treating these disorders.
To emphasize the neurological perspective in understanding these conditions.

Main Methods:

Literature review of neurological syndromes impacting the eye.
Focus on conditions with overlapping ocular and neurological signs.
Emphasis on a neurologist's viewpoint.

Main Results:

Identified key neurological syndromes: multiple sclerosis, Vogt-Koyanagi-Harada disease, autoimmune syndromes, and infectious diseases.
Highlighted diagnostic similarities and challenges.
Stressed the importance of considering neurological involvement.

Conclusions:

Accurate diagnosis requires recognizing shared ocular and neurological features.
Neurological assessment is crucial for managing patients with these complex disorders.
This review serves as a diagnostic and treatment aid for clinicians.