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[Influence of yi nao capsule on epinephrine and norepinephrine during rat ischemia]
Raohong Sun1, Yu Cai, Yanfeng Dou
1Shangrao Company of Jiangxi Pharmaceutical Group, 334000.
Objective:
To investigate the effect of home-made "Yi Nao Capsule" on epinephrine and norepinephrine levels in rat plasma during brain ischemia.
Methods:
Experiments were performed on 180 - 220 g rat under chloral hydrate anesthesia. Brain ischemia was induced by bilateral common carotid ligation for 30 min. HPLC combined with electrochemical detection has been developed for the determination of epinephrine and norepinephrine in plasma samples.
Results:
Epinephrine and norepinephrine concentration increased markedly (P<0.05) in brain ischemia rat. While the ischemia animal was fed on "Yi Nao capsule" priors to ischemia 30 min, norepinephrine and epinephrine conecentration decreased markedly (P<0.05).
Conclusion:
Ischemia induced by bilateral common carotid ligation leads to the increase of plasma epinephrine and norepinephrine and "Yi Nao capsule" can prevent this increase.
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