[Comparison of outcomes and complications between antegrade and retrograde approach to open radical prostatectomy]

To compare the operative outcomes and complications between an anterograde versus retrograde approach to open radical retropubic prostatectomy (RRP);

Retrospectively analyze the clinical data and follow-up results of 76 prostate cancer patients who received radical retropubic prostatectomy from April 2006 to May 2011. According to the resection approach of prostate, the patients were divided into two groups, antegrade RRP group (45 cases) and retrograde RRP group (31 cases). The operative outcomes and complications between two groups were analyzed.

There was no peri-operative death and cancer specific death during the follow-up. Eleven cases were found positive surgical margin, 5 (11.1%) in antegrade group, 6 (19.3%) in retrograde group. The estimated blood loss of these 76 operations were 230-1200 mL [mean (367.2 +/- 132.4) mL], (324.0 +/- 70.3) mL in antegrade group and (429.8 +/- 172.3) mL in retrograde group, respectively. The volume of blood loss between the two groups was significantly different. The durations of follow-up for the patients were 2-63 months [(24.22 +/- 13.21) months), 4 cases showed biochemical failure with criterion as prostate specific antigen > 0.2 microg/L, 2 patients had stress incontinence of antegrade RRP group and 1 patient had permanent incontinence of retrograde RRP group, there were no significant difference between the two groups.

Antegrade radical prostatectomy provides a low incidence of complications, reduced blood loss for localized prostatic cancer.