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Related Concept Videos

Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

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Related Experiment Video

Updated: May 23, 2026

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

Is it important to classify ischaemic stroke?

M Iqbal1, S Bilal, S Sarwar

  • 1University College Hospital, Newcastle Rd, Galway. mudassir213@hotmail.com

Irish Medical Journal
|March 30, 2012
PubMed
Summary
This summary is machine-generated.

Many ischemic strokes are cryptogenic. This study found that clinical assessment and treatment for acute ischemic stroke were not always tailored to the stroke mechanism, indicating diagnostic and therapeutic deficiencies.

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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Area of Science:

  • Neurology
  • Clinical Medicine
  • Cardiology

Background:

  • Cryptogenic ischemic events account for a significant proportion of strokes.
  • Accurate etiological diagnosis is crucial for effective stroke management and secondary prevention.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of ischemic stroke based on medical records.
  • To assess the adherence to established criteria (TOAST) in clinical practice.
  • To identify potential deficiencies in patient assessment and treatment strategies.

Main Methods:

  • Retrospective analysis of 90 patients presenting with acute stroke.
  • Application of the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria to clinical information.
  • Review of patient data including demographics, stroke type, and treatment modalities.

Main Results:

  • 67% of patients had a total/partial anterior circulation stroke, 5.6% had lacunar stroke, and 28% had an unidentified stroke mechanism.
  • Inappropriate treatments were observed, such as anticoagulation for small vessel disease and antiplatelet therapy for atrial fibrillation.
  • Deficiencies in clinical assessment and non-tailored treatment approaches were identified.

Conclusions:

  • There are notable deficiencies in the clinical assessment of patients with acute ischemic stroke.
  • Treatment strategies are not consistently tailored to the identified stroke mechanism.
  • Improved diagnostic accuracy and adherence to treatment guidelines are necessary for better patient outcomes.