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Related Concept Videos

Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Chromatin Structure and RNA Splicing02:41

Chromatin Structure and RNA Splicing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...

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Updated: May 23, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

Epigenetic features are significantly associated with alternative splicing.

Yuanpeng Zhou1, Yulan Lu, Weidong Tian

  • 1State Key Laboratory of Genetic Engineering, Institute of Biostatistics, School of Life Science, Fudan University, Shanghai, China.

BMC Genomics
|March 30, 2012
PubMed
Summary

Epigenetic factors like DNA methylation and histone modifications are strongly linked to alternative splicing (AS). This study reveals distinct patterns of association, classifying AS types based on epigenetic feature involvement.

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Area of Science:

  • Molecular Biology
  • Genomics
  • Epigenetics

Background:

  • Alternative splicing (AS) significantly increases protein diversity.
  • The interplay between different AS types and epigenetic factors is not well understood.

Purpose of the Study:

  • To investigate the association between various epigenetic features and alternative splicing.
  • To classify AS types and epigenetic features based on their association patterns.

Main Methods:

  • Analysis of associations between multiple epigenetic features (DNA methylation, histone modifications, etc.) and AS.
  • Clustering of epigenetic features and AS types based on observed association patterns.

Main Results:

  • Epigenetic features such as DNA methylation, nucleosome occupancy, histone modifications (e.g., H3K36me3), and protein factors (e.g., RNA Pol II) show strong associations with AS.
  • Epigenetic features were clustered into four groups based on association patterns with AS.
  • AS types were classified into two main categories: exon skipping related processes (ESRP) and alternative splice site selection processes (ASSP).

Conclusions:

  • Epigenetic features play a crucial role in regulating alternative splicing.
  • The identified associations provide a framework for understanding epigenetic control of AS.