Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Attitudes of specialist memory-clinic patients with early symptomatic Alzheimer's disease towards lecanemab: results from a multicenter survey in Europe.

Scientific reports·2026
Same author

Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice.

Nature neuroscience·2026
Same author

Hnrnpa1 is essential for early zebrafish development and lipid metabolism: insights from a novel zebrafish knockout model.

Frontiers in cell and developmental biology·2026
Same author

AETA peptide contributes to Alzheimer's disease signature of synapse dysfunction.

Acta neuropathologica·2026
Same author

Tracking of Neuroinflammation Dynamics During Combined Anti-β-Amyloid Therapy (AAT) and Immunomodulation in a Preclinical Alzheimer's Disease Model.

International journal of molecular sciences·2026
Same author

Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: May 23, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration
09:07

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Published on: March 17, 2014

BACE1 dependent neuregulin processing: review.

Daniel Fleck1, Alistair N Garratt, Christian Haass

  • 1German Center for Neurodegenertive Diseases & Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, 80336 Munich, Germany.

Current Alzheimer Research
|March 30, 2012
PubMed
Summary

Neuregulin-1 (NRG1) proteolysis by BACE1 is crucial for peripheral nerve myelination and ErbB signaling. This process is vital for nervous system development and may be relevant to Alzheimer's disease (AD).

More Related Videos

Analyzing Murine Schwann Cell Development Along Growing Axons
09:46

Analyzing Murine Schwann Cell Development Along Growing Axons

Published on: November 21, 2012

Related Experiment Videos

Last Updated: May 23, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration
09:07

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Published on: March 17, 2014

Analyzing Murine Schwann Cell Development Along Growing Axons
09:46

Analyzing Murine Schwann Cell Development Along Growing Axons

Published on: November 21, 2012

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • Neuregulin-1 (NRG1) is a vital signaling molecule involved in nervous system development, cardiogenesis, and mammary gland development.
  • NRG1 signaling through ErbB receptors is implicated in schizophrenia and its dysregulation.
  • The precise role of NRG1 cleavage in its in vivo functions remained unclear until recently.

Purpose of the Study:

  • To summarize current knowledge on the role of NRG1 proteolysis in ErbB receptor-mediated signaling.
  • To highlight the function of BACE1 in NRG1 processing during development.
  • To explore the implications of NRG1 proteolysis in Alzheimer's disease.

Main Methods:

  • Review of existing biochemical and genetic studies on NRG1 and BACE1.
  • Analysis of data from mutant mouse models lacking BACE1 or NRG1 signaling.
  • Synthesis of findings regarding NRG1 cleavage and its downstream effects.

Main Results:

  • NRG1 is a major physiological substrate of β-secretase 1 (BACE1) during early postnatal development.
  • Mice lacking BACE1 exhibit severe peripheral nerve hypomyelination, mirroring NRG1/ErbB signaling deficiencies.
  • BACE1-dependent activation of NRG1 is proposed to be essential for peripheral myelination.

Conclusions:

  • NRG1 proteolysis, particularly by BACE1, is critical for proper myelination in the peripheral nervous system.
  • Understanding NRG1 cleavage provides insights into developmental processes and potential therapeutic targets for neurological disorders.
  • Further research into NRG1 proteolysis may illuminate its role in Alzheimer's disease pathogenesis.