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Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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Prodrugs

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Related Experiment Video

Updated: May 23, 2026

Synthesis and Characterization of Supramolecular Colloids

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

Supramolecular approaches for drug development.

K Kawakami¹, M Ebara, H Izawa

¹World Premier International Research Center for Materials Nanoarchitectonics, National Institute for Materials Science, Namiki, Tsukuba, Japan. KAWAKAMI.Kohsaku@nims.go.jp

Current Medicinal Chemistry

|March 30, 2012

Summary

This summary is machine-generated.

Supramolecular systems like liposomes and microemulsions serve as advanced drug carriers, enhancing drug delivery and therapeutic outcomes. These systems offer improved drug solubility, bioavailability, and targeted delivery for various medical applications.

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Published on: December 1, 2020

Area of Science:

* Pharmaceutical Sciences
* Materials Science
* Nanotechnology

Background:

* Supramolecular systems offer versatile platforms for drug delivery.
* Conventional drug formulations often face challenges with solubility, stability, and targeted delivery.
* Various supramolecular architectures, including liposomes, micelles, and emulsions, are explored for pharmaceutical applications.

Purpose of the Study:

* To review representative supramolecular drug delivery systems.
* To highlight the potential of these systems in improving drug physicochemical and pharmacokinetic properties.
* To discuss the functionalization of supramolecular systems for targeted drug delivery.

Main Methods:

* Review of existing literature on supramolecular drug delivery systems.
* Discussion of established and emerging supramolecular carrier types (liposomes, microemulsions, polymer micelles, etc.).
* Analysis of functionalization strategies for enhanced drug targeting.

Main Results:

* Liposomes are established carriers with marketed formulations for fungal infections, cancer, and macular degeneration.
* Microemulsions improve oral bioavailability of poorly soluble drugs, exemplified by Neoral®.
* Polymer micelles are emerging as promising carriers, with some formulations in clinical trials.
* Functionalization enables precise drug targeting to specific sites within the body.

Conclusions:

* Supramolecular systems significantly enhance drug delivery by modifying physicochemical and pharmacokinetic profiles.
* These systems hold potential for improving the efficacy and usability of existing and novel drug candidates.
* Tailoring supramolecular components allows for targeted delivery, optimizing therapeutic effects and minimizing side effects.