Related Experiment Video
Updated: May 23, 2026

The Establishment of a Murine Maxillary Orthodontic Model
Published on: October 27, 2023
[Cervical vertebrae: Mandibular growth dynamism indicators?]
Monique Raberin1, Ilinca Cozor, Stéphanie Gobert-Jacquart
1142, avenue des Frères Lumière, 69008 Lyon, France - Faculté d'Odontologie, rue Guillaume Paradin, 69008 Lyon, France.
This study found significant correlations between skeletal maturation indicators and cervical vertebrae maturation stages. Mandibular growth increases notably between stages CVS 4 and CVS 5, informing optimal orthodontic treatment timing.
Area of Science:
- Orthodontics
- Growth and Development
- Skeletal Biology
Background:
- Assessing skeletal maturation is crucial for determining optimal timing for orthodontic interventions in Class II discrepancies.
- Cervical vertebrae maturation (CVS) and hand-wrist maturation are commonly used indicators of skeletal maturity.
Purpose of the Study:
- To investigate the relationship between different skeletal maturation indices and cervical vertebrae maturation stages.
- To identify specific maturation stages associated with significant mandibular growth.
- To provide guidance for optimizing orthodontic treatment timing based on maturation indicators.
Main Methods:
- A retrospective longitudinal study of 103 patients (69 girls, 34 boys) aged 11–16 years with Class II skeletal discrepancy.
- Correlation analysis between Björk stages (MP3=, MP3 cap, MP3 U) and Lamparski's cervical vertebrae maturation stages (CVS 2–6).
- Evaluation of mandibular growth changes in relation to identified maturation stages.
Main Results:
- Significant correlations were observed between Björk stages and Lamparski stages (CVS 2, CVS 3–4, CVS 5–6).
- A notable increase in mandibular length was identified between CVS 4 and CVS 5.
- Mandibular growth appears to continue beyond the MP3 U stage or CVS 5 stage.
Conclusions:
- Cervical vertebrae maturation stages correlate significantly with specific skeletal maturation indicators.
- The period between CVS 4 and CVS 5 represents a phase of substantial mandibular growth, suggesting responsiveness to stimulation.
- These findings help refine the timing of orthodontic therapy for improved outcomes in patients with Class II discrepancies.
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