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Ring-opening polymerization in carnosine under pressure.

Chitra Murli¹, A K Mishra, Susy Thomas

¹High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai, India. cmurli@barc.gov.in

The Journal of Physical Chemistry. B

|March 30, 2012

Summary

This summary is machine-generated.

High pressure experiments reveal carnosine (a dipeptide) undergoes ring-opening polymerization of its imidazole ring above 2.8 GPa. The resulting polymer remains stable when pressure is released.

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Area of Science:

Biochemistry
Materials Science
Physical Chemistry

Background:

Carnosine is a naturally occurring dipeptide composed of L-histidine and β-alanine.
Understanding the behavior of biomolecules under extreme conditions is crucial for various scientific fields.

Purpose of the Study:

To investigate the effects of high pressure on the molecular structure and potential transformations of carnosine.
To explore the pressure-induced polymerization of carnosine and its stability.

Main Methods:

High pressure Raman scattering experiments were conducted on carnosine.
Varying pressure conditions were applied, ranging up to 12 GPa.
Raman spectra were analyzed to identify structural changes and polymerization.

Main Results:

Pressure-induced ring-opening polymerization of the imidazole ring in carnosine was observed.
Polymerization initiated at approximately 2.8 GPa, with significant polymerization occurring by 12 GPa.
The polymerized form of carnosine did not exhibit any Raman modes of the ambient phase upon release of pressure.

Conclusions:

Carnosine can undergo irreversible polymerization under high pressure conditions.
The imidazole ring of carnosine is susceptible to pressure-induced ring-opening polymerization.
The resulting polymer is stable at ambient conditions, suggesting potential for novel material applications.