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Related Concept Videos

Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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Related Experiment Video

Updated: May 23, 2026

Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization
08:57

Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization

Published on: October 6, 2019

IRF7, a functional factor associates with systemic lupus erythematosus.

Wang-Dong Xu1, Yu-Jing Zhang, Ke Xu

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China.

Cytokine
|March 30, 2012
PubMed
Summary

Systemic lupus erythematosus (SLE) involves genetic and environmental factors. Research highlights the role of Interferon regulatory factor 7 (IRF7) in SLE pathogenesis, suggesting its potential as a therapeutic target.

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Last Updated: May 23, 2026

Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization
08:57

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Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Area of Science:

  • Immunology
  • Genetics
  • Autoimmune Diseases

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease influenced by genetic and environmental factors.
  • Type I interferons, particularly IFN-α, are implicated in SLE pathogenesis.
  • IFN regulatory factor 7 (IRF7) plays a role in regulating IFN-α and has been linked to SLE onset.

Purpose of the Study:

  • To explore the association between IRF7 and SLE.
  • To elucidate the potential mechanisms of IRF7 in SLE pathogenesis.

Main Methods:

  • Review of recent scientific literature on IRF7 and SLE.
  • Analysis of genetic studies investigating single nucleotide polymorphisms (SNPs) in or near IRF7.
  • Examination of research on IRF7 expression and function in SLE.

Main Results:

  • Single nucleotide polymorphisms (SNPs) near or within the IRF7 gene are associated with an increased risk of SLE.
  • Dysregulation of IRF7 expression and function is observed in patients with SLE.
  • IRF7's role in interferon signaling pathways is critical to its involvement in SLE.

Conclusions:

  • IRF7 is a significant genetic factor associated with SLE.
  • Understanding IRF7's mechanisms in SLE is crucial for developing targeted therapies.
  • Further research into IRF7 modulation may offer new avenues for SLE treatment.