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Updated: May 23, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
Chronological change in pulmonary vascular response to hypoxia in hepatopulmonary syndrome
Yoshinori Tanino1, Hironi Makita, Ichizo Tsujino
1First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan. ytanino@fmu.ac.jp
Abstract:
Here we present a case of hepatopulmonary syndrome (HPS) where spontaneous resolution of severe hypoxaemia occurred with the development of pulmonary hypertension over several years after the initial diagnosis of HPS. The pulmonary vascular responses to hypoxia examined before and after the spontaneous resolution of HPS confirmed that the pathogenesis of HPS could be functional and reversible in nature. To the best of our knowledge, this is the first report demonstrating a remarkable change in the pulmonary vascular response to hypoxia before and after the spontaneous resolution of hypoxaemia in HPS.
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