Related Experiment Video
Updated: May 23, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
[Commentary on the 2010 ESC guidelines on device therapy in heart failure ]
C W Israel1, S D Anker, G Hasenfuss
1Klinik für Innere Medizin – Kardiologie, Diabetologie und Nephrologie, Evangelisches Krankenhaus Bielefeld, Burgsteig 13, 33617 Bielefeld. Carsten.Israel@evkb.de
Updated heart failure guidelines expand cardiac resynchronization therapy (CRT) indications for NYHA class II patients with left bundle branch block. Device therapy now includes more heart failure patients, improving treatment options.
Area of Science:
- Cardiology
- Medical Device Therapy
- Heart Failure Management
Context:
- The 2010 focused update of European Society of Cardiology (ESC) guidelines addresses device therapy for heart failure.
- Previous guidelines are specified, and new findings are incorporated, particularly for NYHA class II patients.
Purpose:
- To present the renewed guidelines on pacemakers and cardiac resynchronization therapy (CRT) for heart failure treatment.
- To outline expanded indications for device therapy based on recent study findings.
Summary:
- Cardiac resynchronization therapy (CRT) is now indicated for NYHA class III and IV heart failure patients regardless of left ventricular dilatation.
- CRT indications are expanded to include NYHA class II patients with specific left bundle branch block and QRS duration criteria.
- Device therapy, including left ventricular assist devices for end-stage heart failure, is broadened.
- CRT is recommended for heart failure patients with permanent atrial fibrillation and specific QRS durations.
- In patients requiring pacemakers for AV block, CRT is generally indicated to prevent heart failure progression.
Impact:
- Expanded indications for CRT and device therapy in heart failure management.
- Improved treatment strategies for heart failure patients, especially those in NYHA class II.
- Highlights areas requiring further investigation in randomized trials, such as CRT in permanent atrial fibrillation and heart block.
More Related Videos
Related Concept Videos
Heart Failure VI: Adjunct Therapies
Heart Failure V: Medical Management
Heart Failure IV: Classification and Diagnostic Evaluation
Cardiomyopathy V: Interprofessional Care
Heart Failure VII: Nursing Interventions
Heart Failure II: Pathophysiology

