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Related Experiment Video

Updated: May 23, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Cellular immunotolerance in the transplant.

Marcos Lóez-Hoyos¹, David San Segundo, Manuel Arias

¹Immunology Unit, Marqués de Valdecilla University Hospital, Santander, Cantabria, Spain. inmlhm@humv.es

Advances in Experimental Medicine and Biology

|March 30, 2012

Summary

Operational tolerance in transplantation is achievable by understanding immune responses and leveraging regulatory T cells. Strategies focus on T-lymphocytes and B-lymphocytes to prevent chronic rejection and enhance transplant success.

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Last Updated: May 23, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

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Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

Area of Science:

Immunology
Transplantation Science

Background:

Operational tolerance observed in some transplant recipients discontinuing immunosuppression.
Advances in immunology fuel interest in translating tolerance induction from models to clinical transplantation.

Purpose of the Study:

To explore strategies for inducing immune tolerance in transplantation.
To highlight the role of T-lymphocytes and B-lymphocytes in immune response and rejection.

Main Methods:

Focus on T-lymphocyte targeting, particularly CD4(+) T cells.
Consideration of alloantibody-producing B-lymphocytes in chronic rejection.
Investigating central and peripheral tolerance mechanisms.

Main Results:

Regulatory T cells (Tregs, Tr1, Th3) play a significant role in active immune suppression.
These regulatory cells offer therapeutic potential for controlling allogeneic rejection.

Conclusions:

Therapeutic potential of regulatory lymphocyte populations for preventing allogeneic rejection is significant.
Clinical trials are underway using Tregs and Tr1 cells for allogeneic reaction prevention.