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Bone marrow transplantation extends its scope.

Fermín M Sánchez-Guijo¹, Alberto Orfao, María Consuelo Del Cañizo

¹Haematology Department, University Hospital of Salamanca, Spain.

Advances in Experimental Medicine and Biology

|March 30, 2012

Summary

Hematopoietic stem cell transplantation (HSCT) has replaced bone marrow transplantation (BMT) due to stem cells being found beyond bone marrow. HSCT offers a healthier system and allows higher doses of cancer treatments.

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Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice

Published on: December 8, 2023

Area of Science:

Hematology
Immunology
Oncology

Background:

Hematopoietic stem cell transplantation (HSCT) has superseded bone marrow transplantation (BMT) in terminology.
Hematopoietic stem cells (HSCs) are crucial for regenerating the recipient's hematopoietic and immune systems.
HSCs are not exclusively found in bone marrow; they can be mobilized to peripheral blood and collected via apheresis.

Purpose of the Study:

To substitute a compromised hematopoietic system with a healthy one.
To enable the administration of supralethal doses of chemotherapy and/or radiotherapy.
To re-establish hematopoiesis using hematopoietic progenitor cells.

Main Methods:

Mobilization of HSCs from bone marrow to peripheral blood using cytokines.
Collection of mobilized HSCs through apheresis.
Utilizing HSCs from umbilical cord blood, with increasing application.

Main Results:

Successful regeneration of the hematopoietic and immune systems post-HSCT.
Enabling high-dose chemo/radiotherapy for treating various diseases.
Increasing use of umbilical cord blood-derived HSCs.

Conclusions:

HSCT is a vital procedure for treating hematological disorders and enabling aggressive cancer therapies.
Complications can arise from toxicity, cytokine release, graft-versus-host disease (GVHD) in allo-HSCT, and immunosuppressive drugs.
The evolution from BMT to HSCT reflects advancements in stem cell collection and therapeutic applications.