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Updated: May 23, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Experimental venous thrombi: MRI characteristics with histopathological correlation

M Ichiki1, Y Sakai, M Nango

  • 1Department of Radiology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan. s500820@nifty.com

The British Journal of Radiology
|March 30, 2012
PubMed
Abstract

Insights

Magnetic resonance imaging (MRI) reveals distinct changes in venous thrombus over time, correlating with histopathology. These temporal MRI characteristics reflect red blood cell (RBC) breakdown and tissue organization, aiding in understanding thrombus evolution.

Area of Science:

  • Radiology
  • Vascular Imaging
  • Histopathology

Background:

  • Venous thrombus characterization is crucial for diagnosis and treatment.
  • Understanding the temporal evolution of thrombus MRI characteristics is essential.

Purpose of the Study:

  • To evaluate the temporal MRI characteristics of venous thrombus.
  • To correlate MRI findings with histopathological changes in a porcine model.

Main Methods:

  • Inferior vena cava thrombi were induced in 12 pigs.
  • MRI was performed at 2 hours, 1 day, 3 days, and 2 weeks post-induction.
  • MRI characteristics were analyzed and correlated with histopathology.

Main Results:

  • Early thrombi (2 hours) showed isointensity on T1WIs and hyperintensity on T2WIs and DWIs.
  • Day 1 thrombi exhibited isointensity on T1WIs, slight T2WIs hyperintensity, and DWI hypointensity.
  • Day 3 thrombi displayed isointensity with peripheral T1WIs hyperintensity and T2WIs/DWIs hypointensity.
  • 2-week thrombi showed isointensity on T1WIs and hyperintensity on T2WIs and DWIs, with RBC lysis and granulation tissue.

Conclusions:

  • Temporal MRI characteristics correlate with red blood cell (RBC) chemical/physical changes and granulation tissue organization.
  • Macrophage-derived free radicals may also influence thrombus MRI appearance.

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