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[Hyperprolactinemia in malignant lymphomas].

N Grobe1, H Rühle, G Eckelmann

  • 1Klinik für Innere Medizin, Bezirkskrankenhaus, Neubrandenburg.

Deutsche Medizinische Wochenschrift (1946)
|November 30, 1990
PubMed
Summary
This summary is machine-generated.

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Elevated serum prolactin levels were observed in some lymphoma patients, potentially acting as a tumor marker. Prolactin levels normalized in some patients upon remission, suggesting a link to lymphoma activity.

Area of Science:

  • Endocrinology
  • Oncology
  • Hematology

Context:

  • Hyperprolactinemia can be associated with various medical conditions.
  • Lymphoma, a cancer of the lymphatic system, can present with diverse clinical manifestations.
  • The role of prolactin in non-pituitary tumors is not fully understood.

Purpose:

  • To investigate serum prolactin levels in patients with Hodgkin and non-Hodgkin lymphoma.
  • To determine if prolactin levels correlate with lymphoma diagnosis, remission, or extranodal involvement.
  • To explore the potential of prolactin as a tumor marker in lymphoma patients.

Summary:

  • Serum prolactin levels were prospectively measured in 36 lymphoma patients (12 Hodgkin, 24 non-Hodgkin).
  • Elevated basal prolactin levels (mean 1900 mU/l) were found in 12 patients, with 8 having extranodal disease.

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  • Prolactin levels normalized in 6 patients at remission; cortisol levels did not correlate, making stress-induced elevation unlikely.

    • Impact:

    • Prolactin may function as a nonspecific tumor marker in lymphoma.
    • Lymphoma should be considered in the differential diagnosis of hyperprolactinemia.
    • Further research is warranted to elucidate the precise role of prolactin in lymphoma pathogenesis and as a biomarker.