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Updated: May 23, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
Identification of two Ia-like alloantigens on rabbit B lymphocytes
K L Knight1, A L Leary, R G Tissot
1Department of Microbiology and Immunology, University of Illinois at the Medical Center, Chicago, Illinois 60680, USA.
Abstract:
Alloimmunizations with rabbit lymphoid cells have resulted in the identification of two cell-surface alloantigens, Ia1 and Ia2. These antigens reside on nearly all B cells; few, if any thymus cells or T cells of mesenteric lymph nodes bear these antigens. Genetic studies showed that Ia1 and Ia2 molecules appear to be controlled by allelic genes at a locus closely linked to the MHC. Immunochemical analyses revealed that Ia1 and Ia2 are glycoproteins and that each is composed of two polypeptide chains of molecular weights of 28 000 and 30 000-32 000. Thus, the alloantigens identified by these two antisera appear to be Ia-like molecules.
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