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Updated: May 23, 2026
07:15
Intranasal Administration of CNS Therapeutics to Awake Mice
Published on: April 8, 2013
Dramatic improvement in sexual function induced by intranasal oxytocin.
1University of California, San Diego Medical Center Department of Psychiatry, San Diego, CA 92103-8218, USA. kai@kaimacdonald.com
The Journal of Sexual Medicine
|March 31, 2012
Summary
Intranasal oxytocin, used for social anxiety, significantly improved male sexual function, including libido, erection, and orgasm. This case highlights oxytocin
Area of Science:
- Neuroendocrinology
- Human sexuality research
Background:
- Oxytocin is increasingly recognized for its positive influence on various aspects of sexual function.
- This case report details a male patient experiencing comprehensive sexual improvements during intranasal oxytocin therapy for social anxiety.
Observation:
- A male patient undergoing treatment for social anxiety and relational difficulties received intranasal oxytocin.
- Pre-existing medical and substance-related issues were ruled out as causes for his sexual dysfunction.
Findings:
- Intranasal oxytocin administration led to notable improvements in libido, erectile function, and orgasm.
- The treatment was well-tolerated by the patient, with no adverse effects reported.
Implications:
- This is the first documented case of broad-spectrum benefits of chronic intranasal oxytocin on male sexual function.
- Future psychiatric trials of oxytocin should include monitoring of sexual function, and dedicated studies on oxytocin's sexual effects are recommended.
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