Related Experiment Video
Updated: May 23, 2026

Orthotopic Liver Transplantation in Rats
Published on: July 1, 2012
The first report of orthotopic liver transplantation in the Western world
R W Busuttil1, L G De Carlis, P V Mihaylov
1Dumont-UCLA Transplant Center, David Geffen School of Medicine at UCLA, Department of Surgery, Los Angeles, CA, USA. rbusuttil@mednet.ucla.edu
Abstract:
Until the present time, the first experimental liver transplant which led to the development of human liver transplantation is attributed to C. Stuart Welch who performed a heterotopic transplant in the canine species in 1955. In 1956, Jack Cannon is credited with the first animal orthotopic liver transplant although the species was not disclosed. This report is intended to set the historical record straight by acknowledging that Vittorio Staudacher in 1952 was the first to perform a liver transplant in a large animal model.

