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Published on: March 1, 2011
Proinflammatory activities of leptin in non-autoimmune conditions
1Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA. ALaCava@mednet.ucla.edu
Abstract:
Leptin is an adipokine whose proinflammatory properties contribute to the pathogenesis of several autoimmune diseases but also to the development and progression of inflammation in several non-autoimmune inflammatory conditions of the kidney, liver, lung, endometrium, blood vessels and endothelia. Here we review the influences of leptin in those conditions and the pertinent experimental work that has defined some mechanisms of action and/or suggested a therapeutic potential for leptin-based modulation of inflammation in non-autoimmune conditions.
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