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Related Experiment Video

Updated: May 23, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Primary cardiac synovial sarcoma.

Tanya Varma¹, Patrick Adegboyega

¹Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. tvarma@lsuhsc.edu

Archives of Pathology & Laboratory Medicine

|March 31, 2012

Summary

This summary is machine-generated.

Primary cardiac synovial sarcoma is a rare heart tumor. Diagnosis is challenging, often requiring molecular genetic techniques like t(X;18) translocation for confirmation.

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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

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Published on: July 28, 2020

Area of Science:

Oncology
Pathology
Genetics

Background:

Primary cardiac synovial sarcoma is an exceptionally rare malignant neoplasm.
Synovial sarcomas can occur in unusual extraskeletal sites, including the heart.

Purpose of the Study:

To review the key features of primary cardiac synovial sarcoma.
To discuss the diagnostic challenges associated with this rare tumor.

Main Methods:

Literature review of primary cardiac synovial sarcoma cases.
Discussion of diagnostic modalities including immunohistochemistry, electron microscopy, and molecular genetic techniques.
Highlighting the significance of the t(X;18) chromosomal translocation.

Main Results:

Primary cardiac synovial sarcoma is exceedingly uncommon, with limited reported cases.
Diagnosis in unusual locations necessitates advanced ancillary techniques.
The t(X;18) translocation is a consistent finding in synovial sarcomas.

Conclusions:

Primary cardiac synovial sarcoma presents significant diagnostic difficulties.
Molecular genetic analysis, particularly the t(X;18) translocation, is crucial for accurate diagnosis.
Further research is needed to understand this rare cardiac malignancy.