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Related Concept Videos

Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: May 23, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Graves' disease presenting with severe cholestasis.

Molly O Regelmann1, Tamir Miloh, Ronen Arnon

  • 1Division of Pediatric Endocrinology and Diabetes, Mount Sinai School of Medicine, New York, New York 10029, USA.

Thyroid : Official Journal of the American Thyroid Association
|March 31, 2012
PubMed
Summary

Severe cholestasis, a rare initial symptom of Graves' disease in adolescents, can be effectively managed. Treatment with methimazole resolved both hyperthyroidism and cholestasis in a teenage patient.

Related Experiment Videos

Last Updated: May 23, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Area of Science:

  • Endocrinology
  • Hepatology
  • Pediatric Endocrinology

Background:

  • Hyperthyroidism, particularly Graves' disease, is known to cause liver function abnormalities.
  • Cholestasis as the primary presenting feature of adolescent Graves' disease is exceptionally rare and previously unreported.

Observation:

  • A 17-year-old female presented with severe cholestasis, initially complicated by a positive hepatitis A IgM antibody.
  • Clinical course, liver histology, and mild transaminase elevation suggested hepatitis A was not the primary driver of cholestasis.
  • Congestive heart failure, autoimmune hepatitis, and other viral infections were ruled out as causes of cholestasis.

Findings:

  • The patient was diagnosed with Graves' disease, a common cause of hyperthyroidism.
  • Treatment with methimazole successfully managed the hyperthyroidism.
  • Resolution of hyperthyroidism correlated with significant improvement in cholestasis.

Implications:

  • This case highlights severe cholestasis as a rare but possible presenting manifestation of Graves' disease in adolescents.
  • Methimazole is a viable treatment option for hyperthyroidism in patients presenting with cholestasis, requiring careful monitoring.
  • Early diagnosis and management of Graves' disease are crucial for resolving associated cholestatic conditions.