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Updated: May 23, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Epstein-Barr virus infection and lymphoproliferative disorder after hematopoietic cell transplantation

Yazhen Zhong1

  • 1University of Texas MD Anderson Cancer Center in Houston, USA. yazhen_z@yahoo.com

Clinical Journal of Oncology Nursing
|March 31, 2012
PubMed

Common herpes viruses such as Epstein-Barr virus (EBV) cause infection and disease after hematopoietic cell transplantation (HCT). Post-transplantation lymphoproliferative disorder following allogeneic HCT is a rare but life-threatening disease, mostly associated with EBV-infected B cells. Anti-CD20 monoclonal antibodies (e.g., rituximab) target normal and infected B cells and further suppress the patient's immune system. This article describes the development of cellular therapies by infusing virus-specific cytotoxic T lymphocytes via IV into patients to create an adoptive immune system for specific viral suppression.

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