[Candidemia and invasive candidiasis in the adult: clinical forms and treatment]

Area of Science:

• Infectious Diseases
• Clinical Pharmacy
• Healthcare Economics

Background:

• Invasive candidiasis incidence is increasing in hospitalized adults.
• New antifungal agents offer improved efficacy and safety but increase treatment complexity and cost.
• Balancing patient outcomes with economic considerations is crucial for managing invasive fungal infections.

Purpose of the Study:

• To review current recommendations for managing invasive candidiasis.
• To analyze strategies for optimizing patient benefit and cost-effectiveness in treatment.
• To cover various forms of invasive candidiasis, including candidemia and organ-specific infections.

Main Methods:

• Systematic review of current clinical guidelines and recommendations.
• Analysis of management strategies for different types of invasive candidiasis.
• Evaluation of treatment costs and patient benefit associated with antifungal therapies.

Main Results:

• The review analyzes recommendations for candidemia and other invasive forms like esophagitis, peritonitis, ocular, cardiovascular, osteoarticular, CNS, and urinary tract candidiasis.
• Management complexity has risen due to new, effective, but costly antifungal drugs.
• A key objective is to balance optimal patient care with economic feasibility.

Conclusions:

• Effective management of invasive candidiasis requires careful consideration of new antifungal options.
• Recommendations aim to achieve a balance between therapeutic benefit and healthcare costs.
• Addressing the rising incidence and complexity of invasive candidiasis is essential for patient outcomes.