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Topical urea in dermatology
P K Banerjee1, A K Choudhury, S K Panja
1Dept. of Dermatology, Calcutta National Medical College & Hospital.
Indian Journal of Dermatology
|March 1, 1990
Summary
Urea is an effective, inexpensive topical moisturizer and mild keratolytic. Clinical trials show urea enhances hydrocortisone penetration, proving beneficial for various skin conditions.
Area of Science:
- Dermatology
- Cosmetic Science
- Pharmacology
Background:
- Identifying effective, accessible, and affordable cutaneous moisturizers is a long-standing research goal.
- Urea is recognized for its moisturizing properties and mild keratolytic action.
- Its cost-effectiveness and availability make it a promising topical agent.
Purpose of the Study:
- To evaluate the efficacy of topical urea formulations as a cutaneous moisturizer.
- To assess urea's potential to enhance the skin penetration of hydrocortisone.
- To determine the safety and effectiveness of urea in patients with various dermatological disorders.
Main Methods:
- A clinical trial involving over 200 patients with diverse skin conditions was conducted.
- Patients received topical urea applications: urea 10 (10%), urea-20 lotion (20%), or Urea-HC (containing hydrocortisone).
- The agent was applied twice daily for up to 8 weeks.
Main Results:
- Topical urea demonstrated significant efficacy as a moisturizer across the studied patient group.
- Urea formulations, particularly Urea-HC, promoted enhanced penetration of hydrocortisone into the skin.
- The treatments were generally well-tolerated over the 8-week study period.
Conclusions:
- Urea is a highly effective and economical option for cutaneous moisturization.
- Urea-based formulations can improve the efficacy of topical corticosteroids like hydrocortisone.
- Topical urea represents a valuable therapeutic agent for managing various dermatological conditions.