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Defining rewardable innovation in drug therapy
Jeffrey K Aronson1, Robin E Ferner, Dyfrig A Hughes
1Department of Primary Health Care, University of Oxford, 23-38 Hythe Bridge Street, Oxford OX1 2ET, UK. jeffrey.aronson@phc.ox.ac.uk
Nature Reviews. Drug Discovery
|March 31, 2012
Summary
Defining
Area of Science:
- Pharmaceutical Sciences
- Health Economics
Background:
- Incentivizing the development of novel medicines is crucial for public health.
- Existing reward mechanisms often lack clear criteria for 'rewardable innovation' in pharmaceuticals.
Purpose of the Study:
- To propose a clear definition of innovation for medicinal products.
- To establish a framework for ranking different types of pharmaceutical innovation.
- To provide a basis for developing effective reward systems for drug developers.
Main Methods:
- Conceptual analysis of existing literature on pharmaceutical innovation.
- Development of a multi-criteria definition for 'rewardable innovation'.
- Expert consultation and consensus-building on innovation typologies.
Main Results:
- A comprehensive definition of medicinal product innovation is presented.
- A tiered ranking system for different types of innovation (e.g., first-in-class, best-in-class) is proposed.
- The framework distinguishes between incremental and breakthrough innovations.
Conclusions:
- A standardized definition and ranking system are essential for fair and effective reward mechanisms.
- Implementing such a system can better incentivize the development of truly innovative medicines.
- This framework supports policy decisions regarding pharmaceutical R&D investment and intellectual property.
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