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Intestinal healing in rats submitted to ethanol ingestion
Rodrigo Severo de Camargo Pereira1, Cláudia Nishida Hasimoto, Leonardo Pelafsky
1Division of Gastroenterology Surgery, Surgery and Orthopedics Department, Botucatu School of Medicine, UNESP, Brazil. rodrigomacarena@yahoo.com.br
Purpose:
To study the effect of alcoholism on intestinal healing and postoperative complications in rats
Methods:
One hundred and sixty rats were divided into two groups: control and treated. The control group received water and the treated group 30% ethanol. After 180 days, colotomy with anastomosis were performed. After, the groups were divided into four subgroups: 20 rats for study at the following moments: 4(th), 7(th), 14(th) and 21(st) postoperative. The analyzed parameters were: weight gain, breaking strength, tissue hydroxyproline, postoperative complications and histopathological study
Results:
Weight gain was greater in the control group (p<0.05). When all the subgroups were clustered, breaking strength was significantly greater in the control (p<0.05). Histopathology and hydroxyproline dosage did not show differences. There were five surgical site infections in the treated group while the control group showed two (p>0.05). Nine fistulas occurred in the treated group whereas the control group two (p<0.05). There were three deaths in the control group and seven in the treated group (p>0.05).
Conclusions:
Treated group undergo a malnutrition process that is revealed by lower weight gain. Impaired intestinal healing as indicated by smaller breaking strength. There were a larger number of postoperative complications in the treated animals.
