Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

Acute Kidney Injury I: Introduction

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Markers of Kidney Tubule Secretion and Future Risk of Sepsis-Associated Acute Kidney Injury Among REGARDS Participants.

Kidney medicine·2025

Same author

Difference in Cystatin C-Based and Creatinine-Based eGFR and Cognition in Osteoporotic Fracture in Men Study.

Kidney360·2025

Same author

Another Note of Caution for Spironolactone: Implications of the BARACK-D Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2025

Same author

Estimates of eskd risk and timely kidney replacement therapy education.

BMC nephrology·2024

Same author

Reply to "Comment on: Difference between kidney function by cystatin C versus creatinine and association with muscle mass and frailty".

Journal of the American Geriatrics Society·2024

Same author

Renal Reinforcements: Slowing Diabetic Kidney Disease with Multiple New Agents.

Journal of the American Society of Nephrology : JASN·2024

Search research articles

Related Experiment Video

Updated: May 23, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Does AKI truly lead to CKD?

Dena E Rifkin¹, Steven G Coca, Kamyar Kalantar-Zadeh

¹Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 West Carson Street, C1-Annex, Torrance, CA 90509-2910, USA.

Journal of the American Society of Nephrology : JASN

|March 31, 2012

Summary

This summary is machine-generated.

Acute kidney injury (AKI) may increase chronic kidney disease (CKD) risk, but evidence is inconclusive. More rigorous studies are needed to confirm if AKI directly causes CKD.

More Related Videos

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Published on: February 10, 2026

Related Experiment Videos

Last Updated: May 23, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Published on: February 10, 2026

Area of Science:

Nephrology
Epidemiology
Clinical Research

Background:

Observational studies suggest acute kidney injury (AKI) is an independent risk factor for chronic kidney disease (CKD).
The nephrology community generally presumes a causal link between AKI and CKD.
Potential biases and misclassifications challenge the certainty of this causal relationship.

Purpose of the Study:

To critically examine the evidence for a causal relationship between AKI and CKD using Hill's causality criteria.
To identify limitations in current research that prevent definitive conclusions about AKI causing CKD.
To outline the requirements for future studies to clarify the AKI-CKD association.

Main Methods:

Review of existing literature on AKI and CKD.
Application of Hill's causality criteria to assess the strength of evidence.
Identification of confounding factors, biases, and misclassification issues in observational studies.

Main Results:

Current evidence is insufficient to definitively establish AKI as a cause of CKD.
Residual confounding, ascertainment bias, and outcome misclassification are significant limitations.
Several of Hill's causality criteria are not adequately met by existing studies.

Conclusions:

The causal nature of the AKI-CKD relationship remains uncertain in the general population.
Well-designed prospective studies with rigorous kidney function assessment are necessary.
Randomized controlled trials investigating AKI prevention/treatment effects on CKD incidence are required.