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Related Experiment Videos

Contact hypersensitivity induces plasma interleukin 6.

I Kimber1, M Cumberbatch, M Humphreys

  • 1ICI Central Toxicology Laboratory, Alderley Park, Macclesfield, UK.

International Archives of Allergy and Applied Immunology
|January 1, 1990
PubMed
Summary

Contact reactions in mice show increased levels of acute-phase proteins and interleukin 6 (IL-6). Measuring IL-6 may help evaluate allergic contact dermatitis in research settings.

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Area of Science:

  • Immunology
  • Dermatology
  • Biochemistry

Background:

  • Previous studies linked contact-sensitized mice reactions to elevated acute-phase proteins.
  • Interleukin 6 (IL-6) is known to regulate hepatic synthesis of acute-phase proteins.

Purpose of the Study:

  • To investigate the association between contact reactions and plasma interleukin 6 (IL-6) concentrations.
  • To explore the potential of IL-6 as a serological marker for experimental allergic contact dermatitis.

Main Methods:

  • Quantitatively assessed plasma IL-6 concentrations in contact-sensitized mice.
  • Correlated IL-6 levels with elicitation reactions.

Main Results:

  • Contact reactions were associated with a rapid and substantial increase in plasma IL-6.
  • Elevated IL-6 levels were observed in conjunction with elicitation reactions.

Conclusions:

  • Plasma IL-6 concentration increases significantly during contact reactions in mice.
  • Quantitative assessment of IL-6 may serve as a valuable serological method for evaluating experimental allergic contact dermatitis in mice and potentially other species.

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