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Related Concept Videos

Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Angina III: Clinical Manifestations and Assessment

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Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Antidotes01:17

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Related Experiment Video

Updated: May 23, 2026

Human In-Vivo Bioassay for the Tissue-Specific Measurement of Nociceptive and Inflammatory Mediators
08:54

Human In-Vivo Bioassay for the Tissue-Specific Measurement of Nociceptive and Inflammatory Mediators

Published on: December 1, 2008

CCN3: the-pain-killer inside me.

Bernard Perbal1,

  • 1International CCN Society, Paris, France, bperbal@gmail.com.

Journal of Cell Communication and Signaling
|March 31, 2012
PubMed
Summary
This summary is machine-generated.

This study questions the direct link between CCN3 and matrix metalloproteinases (MMPs) in inflammatory pain, suggesting more research is needed to understand CCN3

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Last Updated: May 23, 2026

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04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pain Research

Background:

  • Matrix metalloproteinases (MMPs) are increasingly implicated in neuropathic pain.
  • Identifying molecules that regulate MMP2 and MMP9 is crucial for pain management.
  • CCN3 has been proposed to decrease inflammatory pain by regulating MMP2 and MMP9.

Purpose of the Study:

  • To critically evaluate the evidence linking CCN3 to MMP regulation in inflammatory pain.
  • To assess the validity of claims that CCN3 modulates MMP2 and MMP9 activity in pain pathways.
  • To highlight the need for further research into the mechanisms of CCN3 in pain sensing.

Main Methods:

  • Analysis of experimental data on CCN3 expression and MMP levels in response to induced inflammation.
  • Review of studies investigating the effects of MMP inhibition and CCN3 modulation (siRNA).
  • Examination of CCN3's partial effects on MMP expression following intrathecal injection.

Main Results:

  • The study's conclusions regarding CCN3's role in regulating MMPs are weakened by a lack of direct experimental evidence.
  • Some findings presented by Kular et al. confirm previously established data by other researchers.
  • Previous studies have reported CCN3's repressive effect on MMP9 and its role in inflammatory processes.

Conclusions:

  • The simultaneous observation of CCN3, MMP9, and MMP2 variations is insufficient to establish a functional relationship.
  • The precise mechanisms by which CCN3 might regulate MMPs in inflammatory pain require thorough investigation.
  • Further studies are necessary to elucidate the significance of CCN3 in pain sensing and its broad biological functions.