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Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats

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Published on: August 31, 2022

Pharmacological agents and bone healing.

Umberto Tarantino¹, Irene Cerocchi, Monica Celi

¹University of Rome Tor Vergata, PTV "Policlinico Tor Vergata" Foundation Division of Orthopaedics and Traumatology, Rome, Italy.

Clinical Cases in Mineral and Bone Metabolism : the Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases

|March 31, 2012

Summary

Osteoporosis impairs fracture healing due to decreased bone mass and altered metabolism. Novel pharmacological agents show promise in enhancing bone repair and osseointegration for at-risk patients.

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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Area of Science:

Orthopedics
Metabolic Bone Disease
Biomaterials Science

Background:

Osteoporosis is a metabolic bone disease characterized by reduced bone mass and microarchitectural deterioration, increasing fracture risk.
The coupling of bone resorption and formation is crucial for skeletal integrity and repair.
Fracture healing involves complex biological processes that can be compromised by osteoporosis and aging.

Purpose of the Study:

To review the impact of osteoporosis on fracture healing and osseointegration.
To explore the potential of pharmacological agents in improving fracture repair in osteoporotic patients.
To discuss the clinical translation of these agents for enhanced fracture treatment.

Main Methods:

Review of preclinical studies and biomechanical testing data.
Analysis of the effects of bisphosphonates, strontium ranelate, and teriparatide on bone repair.
Evaluation of systemic and local administration of therapeutic agents.

Main Results:

Osteoporotic bone exhibits compromised biomechanical properties and slower healing rates.
Pharmacological agents demonstrated potential to enhance osseointegration and stimulate reparative processes in animal models.
Increased risks of implant failure and re-fractures are observed in osteoporotic patients undergoing fracture treatment.

Conclusions:

Osteoporosis significantly complicates fracture healing, posing challenges for surgical treatment and implant fixation.
Pharmacological interventions targeting bone metabolism may offer a valuable therapeutic strategy to improve fracture healing outcomes.
Further clinical translation of these agents could benefit patients with osteoporosis and other conditions impairing bone repair.